karppaus.infon arkistoitu foorumi

Ihminen ei hevin luovu uskomuksistaan. Ehkä pitäisi herättää uteliaisuus ja antaa itse etsiä tietonsa. Tai sitten jotkut vain ansaitsevat kohtalonsa. Se on sitä evoluutiota.

Se edustaa modernistista elämäntapaa, että "mun ei tarvitse kuunnella sun ratkaisua mun sokeritautiin, koska mitään totuuksia ei ole ja tuo kertomasi on kaiken lisäksi ikävästi vastoin kaikkea minulle opetettua ja mun lääkäri ja mun televisio ei ole kertonut tästä mitään".

Ihminen ei hevin luovu uskomuksistaan. Ehkä pitäisi herättää uteliaisuus ja antaa itse etsiä tietonsa. Tai sitten jotkut vain ansaitsevat kohtalonsa. Se on sitä evoluutiota.

The guidelines have long urged people to dodge fats and consume more carbohydrates. This admonition stems from old research that was shaky at best. More rigorous studies since have shown that a high-carb, low-fat diet does nothing to combat obesity or type 2 diabetes. In fact, it worsens diabetes

Metformin, a drug widely used in type 2 diabetes, also activates autophagy but not through mTOR. It increases AMPK, a molecule that signals the energy status of the cell. If AMPK is high, the cell knows that it has insufficient energy and increases autophagy. AMPK senses the ADP/ATP ratio, thus knowing the cellular energy levels — sort of like a fuel gauge but in reverse. High AMPK, low cellular energy status. High AMPK levels directly and indirectly activate autophagy, but also mitochondrial production.


Mitophagy is the selective targeting of defective or dysfunctional mitochondrion. These are the parts of the cell that produce energy — the power houses. If these are not working properly, then the process of mitophagy targets them for destruction. The critical regulators of this process includes the notorious tumor suppressor gene PTEN. This may initially seem bad, remember that, at the same time that mitophagy is increased, new mitochondrion are being stimulated to grow. AMPK for example, will stimulate mitophagy as well as new mitochondrion growth — essentially replacing old mitochondrion with new ones in a renewal process. This is fantastic — essentially a complete renovation of the mitochondrial pool. Break down the old, junky mitochondrion and stimulate the body to build new ones. This is one of the reasons metformin is commonly promoted as an anti-aging compound — not so much for its blood sugar effects, but instead because of its effect on AMPK and autophagy.

Discussion
This case report demonstrates that therapeutic fasting in conjunction with a low-carbohydrate diet can be an effective treatment option for T2D. The treatment worked quickly to reduce blood glucose and insulin resistance. Despite over a decade of insulin usage, the patient was able to completely discontinue his insulin treatment in only 4 months of dietary treatment. Simultaneously, he reduced his glycated haemoglobin levels, weight and waist circumference, indicating that the underlying insulin resistance of T2D was significantly improved.

"Sammanfattningsvis kan ... kolhydratsnål kost idag sägas vara i överensstämmelse med vetenskap och beprövad erfarenhet för viktreduktion vid övervikt och typ 2 diabetes med motiveringen att ett antal studier har visat effekter i ett kortare perspektiv och att evidens för farlighet inte framkommit i hittills gjorda systematiska litteraturgenomgångar."

I honestly believe the good ideas in nutrition have come from medical doctors, engineers and a few journalists. The harmful ones from dietitians and their (mostly dodgy) professional bodies.

So carbs not such a great idea for diabetics. Who would have guessed? Pretty much what Atkins wrote in 1972 and what I’ve been saying since #ChallengingBeliefs in 2012 and #RealMealRevolution in 2013. Establishes that encouraging persons with diabetes to eat carbs is quackery.

Lágkolvetnismataræði
Skipting orkuefnanna: Prótein 15-30 E% Kolvetni 10-20 E% Fita >50 E%

Conclusion

Currently recommended drug treatments, nutritional guidelines and behavioural interventions have had limited to no success in halting the obesity and diabetes epidemics. This has resulted in exorbitant health care costs122 and indirect costs from lower quality of life123 and lost productivity124 for a growing proportion of the population. The premise of this research project is that excess carbohydrate intake in the Western diet is a major driver of the obesity and diabetes epidemics, and that restricting dietary carbohydrate to a level that permits utilisation of fat as the primary fuel will yield substantial weight loss and improvement in diabetes and metabolic syndrome, other health conditions and overall quality of life. Moreover, we show that for many, a lowcarbohydrate diet is satisfying and sustainable.