Tuore tutkimuskatsaus:1. Hyvin koostettu ketoruokavalio on turvallinen
2. Sen tulisi olla lihavuuden ja diabeteksen ensisijainen hoito
3. Siitä voi olla apua muissakin insuliiniresistenssiin liittyvissä sairauksissa
4. Lisää korkealuokkaista tutkimusta tarvitaan pitkäaikaisvaikutuksista ja siitä, mihin kaikkeen ketoruokavalio oikein pystyykään
Tutkimuskatsauksessaan David S. Ludwig kirjoittaa vähähiilihydraattisista vs. vähärasvaisista ruokavalioista diabeteksen hoidossa mm. näin:
Lainaa:
Low-Carbohydrate Diets Show Promise for Diabetes Treatment
The US NIH sponsored several large multicentered studies of low-fat diets, such as the Women's Health Initiative dietary modification trial (prevention of diabetes as a secondary outcome) (19) and Look Ahead [prevention of cardiovascular disease (CVD) in people with diabetes as the primary outcome] (20). In both cases, the low-fat diet showed no benefit, even though the comparison groups were given lower-intensity interventions. The Diabetes Prevention Program intensive lifestyle intervention reduced incidence of type 2 diabetes among high-risk participants (21), but the multicomponent nature of the intervention (including calorie restriction, fat restriction, exercise, and behavior modification) makes attribution of effects to the low-fat diet problematic. Unfortunately, no comparable studies of very-low-carbohydrate diets have been conducted, but smaller trials and observational studies suggest promise.
A 2019 Consensus Report from the American Diabetes Association concluded that low-carbohydrate diets (including those that aim for nutritional ketosis) “are among the most studied eating patterns for type 2 diabetes” and that these “eating patterns, especially very-low-carbohydrate … have been shown to reduce [Hb]A1C [glycated hemoglobin] and the need for antihyperglycemic medications” (22). In a pragmatic trial including 262 adults with type 2 diabetes assigned to a very-low-carbohydrate diet, mean weight loss was 11.9 kg and HbA1c decreased by 1.0%, even with substantial reductions in the use of hypoglycemic medications other than metformin (23). Few clinical trials have examined carbohydrate restriction in type 1 diabetes, possibly due in part to concerns about hypoglycemia and ketoacidosis. In a survey of 316 children and adults following a very-low-carbohydrate diet for type 1 diabetes, exceptional glycemic control (mean HbA1c = 5.7%), low rates of hypoglycemia and ketoacidosis, an overall healthful CVD risk profile, and high satisfaction with diabetes management were documented (24).
Tuossa Yhdysvaltain diabetesliiton ADA:n konsensusraportissa, jossa todetaan että paras verensokerin hallinta tutkitusti saavutetaan LCHF/ketoruokavaliolla, viitataan Virran ja Indianan yliopiston tutkimukseen (23), josta Suomen viralliset tahot tekeytyvät tietämättömiksi.