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Suolistobakteerit ovat avain kakkostyypin diabeteksen ehkäisyssä – suomalaistutkijat löysivät puuttuvan linkin täysjyväviljan ja terveysvaikutusten väliltä
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Indolipropionihappo syntyy komposti/mädätys tilassa (hapeton) kun Clostridium sporogenes bakteeri syö sitä, vaikka suomalaisesta täysjyväviljasta.
Tossa nyt on parikymmentä patenttia indolipropionihappolle "3-(1H-indol-3-yl)propanoic acid" D2 ehkäisyssä.
Indole-3-propionate (IPA), a deamination product of tryptophan
It is endogenously produced by human microbiota
and has only been detected in vivo when the species Clostridium sporogenes is present in the gastrointestinal tractClostridium sporogenes is a species of Gram-positive bacteria that belongs to the genus Clostridium. Like other strains of Clostridium, it is an anaerobic, rod-shaped bacterium that produces oval, subterminal endospores and is commonly found in soil. Unlike Clostridium botulinum, it does not produce the botulinum neurotoxins. In colonized animals, it has a mutualistic rather than pathogenic interaction with the host.
Clostridium sporogenes colonizes the human gastrointestinal tract, but is only present in a subset of the population; in the intestine, it uses tryptophan to synthesize indole and subsequently 3-indolepropionic acid (IPA) – a type of auxin (plant hormone)
Auxins (plural of auxin /ˈɔːksᵻn/) are a class of plant hormones (or plant growth substances) with some morphogen-like characteristics.
Clostridia are obligate anaerobes: they are unable to use molecular oxygen as a final electron acceptor and generate their energy solely by fermentation. Clostridia exhibit varying degrees of intolerance of oxygen. Some species are sensitive to oxygen concentrations as low as 0.5%, but most species can tolerate concentrations of 3–5%. The sensitivity of clostridia to oxygen restricts their habitat to anaerobic environments; habitats that contain large amounts of organic matter provide optimal conditions for their growth and survival.
indolipropionihappo
(IPA)
Chemical Name
3-Indolepropionic acid
Synonyms
3-(1H-indol-3-yl)propanoic acid
indole propionate
indole-3-propanoic acid
indolepropionic acid
Muuta
Clostridium sporogenes bakteeri on tiukka elektroni transfer jutskissa ilman happea (Microbial fuel cell ym.)
IPA is an even more potent scavenger of hydroxyl radicals than melatonin
3-(1H-indol-3-yl)propanoic acid <-Tonni patentteja D2 jutuissa
L-Alanine etc