http://www.nutritionandmetabolism.com/content/3/1/19
"Research
.
Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease
Richard J Wood , Jeff S Volek , Steven R Davis , Carly Dell'Ova and Maria Luz Fernandez"
...
"Lp(a)
Elevated plasma Lp(a) is a risk factor for cardiovascular disease because of both atherogenic and thrombotic properties [4]. The 12% decrease in plasma Lp(a) is a novel finding considering that plasma Lp(a) levels are reported to have a strong genetic influence [29,30] and that diet usually has little positive influence on Lp(a) levels [5,31]. Important to note is that most diet interventions that have examined Lp(a) response emphasized fat restriction with moderate to high carbohydrate intake, which sharply contrasts the macronutrient contribution in the current intervention.
Reducing total and saturated fat intake has been shown to increase Lp(a) during weight maintenance [32] and have no effect on Lp(a) during weight loss [33]. The significant decrease in Lp(a) in this study suggests that carbohydrate restriction, as opposed to fat restriction, may play a greater role in modulating Lp(a) levels during weight loss. Diets relatively high in trans fatty acids in comparison to saturated or unsaturated fatty acids can significantly increase plasma Lp(a) [34]. Thus, the 38% reduction in trans fatty acid consumption could also have also influenced this parameter.
Reports about weight loss and change in plasma Lp(a) are varied. Significant weight loss achieved via a very-low calorie diet in obese individuals has been shown to both reduce [35] and not reduce plasma Lp(a) [36]. However, a very-low calorie diet and weight loss may only reduce plasma Lp(a) in subjects with elevated baseline values (> 20 mg/dL). Our results are in agreement with previous reports that reductions in plasma Lp(a) correlate strongly with baseline Lp(a), but not with weight loss [36,37]."
Kirjaudu sisään
UKK
Etsi
Ongelmansa kullakin... 