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Intermittent Fasting Improves Memory, Decreases Amyloid Accumulation, in Alzheimer’s Mouse Model
August 22, 2023


Nearly 80% of people with Alzheimer’s disease (AD) experience disruption to the body’s circadian rhythm, including difficulty sleeping and worsening cognitive function at night. Now, a new study from researchers at the University of California (UC), San Diego, School of Medicine has shown, in mice, that it is possible to correct the circadian disruptions seen in AD with time-restricted feeding—a type of intermittent fasting focused on limiting the daily eating window without caloric restriction.

This research is published in Cell Metabolism in the paper, “Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease.”


In the study, mice that were fed on a time-restricted schedule showed improvements in memory and reduced accumulation of amyloid proteins in the brain.

Highlights

•AD mice present circadian deregulation and aberrant time-of-day brain transcription
•TRF modulates hippocampal gene expression and pathways related to AD and inflammation
•Increased Aβ clearance and reduced amyloid deposition mediate TRF benefits
•Time-restricted feeding recovers sleep and activity rhythms and improves cognition
Summary

Circadian disruptions impact nearly all people with Alzheimer’s disease (AD), emphasizing both their potential role in pathology and the critical need to investigate the therapeutic potential of circadian-modulating interventions. Here, we show that time-restricted feeding (TRF) without caloric restriction improved key disease components including behavioral timing, disease pathology, hippocampal transcription, and memory in two transgenic (TG) mouse models of AD. We found that TRF had the remarkable capability of simultaneously reducing amyloid deposition, increasing Aβ42 clearance, improving sleep and memory, and normalizing daily transcription patterns of multiple genes, including those associated with AD and neuroinflammation. Thus, our study unveils for the first time the pleiotropic nature of timed feeding on AD, which has far-reaching effects beyond metabolism, ameliorating neurodegeneration and the misalignment of circadian rhythmicity. Since TRF can substantially modify disease trajectory, this intervention has immediate translational potential, addressing the urgent demand for accessible approaches to reduce or halt AD progression.