Kunhan vaan jaan tämänkin linkin ihan vaan taas jälleen kerran yhtenä esimerkkinä siitä, että terapeuttisesta hiilarirajoituksesta voi olla apua mitä moninaisempien vaivojen ehkäisyssä ja hoidossa. Vähähiilihydraattinen ruokavalio kun vaikuttaa terveyteen kokonaisvaltaisesti. Perimmiltään tämä kokonaisvaltaisuus perustuu siihen, että vhh korjaa häiriöitä mitokönddrioiden toiminnassa.
https://pubmed.ncbi.nlm.nih.gov/37679316/Lainaa:
2023 Sep 7
Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors
Abstract
Insulin signaling often plays a role in the regulation of cancer, including tumor initiation, progression, and response to treatment. In addition, the insulin-regulated PI3K-Akt-mTOR pathway plays an important role in the regulation of islet cell proliferation, and this pathway is hyperactivated in human non-functional pancreatic neuroendocrine tumors (PanNETs). We, therefore, investigated the effect of a very low carbohydrate diet (ketogenic diet) on a mouse model that develops non-functional PanNETs to ask how reduced PI3K-Akt-mTOR signaling might affect the development and progression of non-functional PanNET. We found that this dietary intervention resulted in lower PI3K-Akt-mTOR signaling in islet cells and a significant reduction in PanNET formation and progression. We also found that this treatment had a significant effect on the suppression of pituitary NET development. Furthermore, we found that non-functional PanNET patients with lower blood glucose levels tend to have a better prognosis than patients with higher blood glucose levels. This preclinical study shows that a dietary intervention that results in lower serum insulin levels leads to lower insulin signals within the neuroendocrine cells and has a striking suppressive effect on the development and progression of both pancreatic and pituitary NETs.
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