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A case study of overfeeding 3 different diets
Feltham, Sama; Westman, Eric C.b

Abstract
Purpose of review
Quality or quantity of food has been at the heart of the diet debate for decades and will seemingly continue for many to come unless tightly controlled studies are conducted. To our knowledge, there has never been an overfeeding study comparing the effects of multiple diets.

Recent findings
This study reports a case study of an individual who ate 5800 Calories per day of 3 different diets for 21 days at a time. The 3 different diets were low-carb, low-fat, and very-low-fat vegan. The weight gain over 21 days was 1.3 kg for low-carb, 7.1 kg for low-fat, and 4.7 kg for very-low-fat vegan.

Summary
In this n-of-1 study, consuming 5800 Calories/day of 3 different diets for 21 days did not lead to the same amount of weight gain. Further research should be conducted on how the human body gains weight with an emphasis on how different foods affect physiology. If these findings are replicated, there would be many ramifications for obesity treatment and healthcare guidelines.

Is weight all about calories-in vs. calories-out?

-->An overeating case study: A man ate 5800 calories/day for 3 weeks on 3 different diets.
Resulting weight gain:
Low-carb: 1.3 kg
Low-fat: 7.1 kg
V. low-fat vegan 4.7 kg

Obviously, not all calories produced the same results.

Subject felt best, had most energy on low-carb. Experienced no hunger on low-carb or vegan diets. Was hungry on the low-fat diet (!). Asthma, brain fog, sleep problems returned on low-fat and vegan diets. Excessive bathroom use was "unsettling" on vegan diet.

More info: Exercise was the same. 3-mo. washout period in between each diet to return to baseline

At pub time (2021), this was the only overfeeding experiment comparing low-carb to high-carb diets.