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Abstract

Background:

Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited.

Objective:

To determine whether TRE is more effective for weight control and cardiometabolic risk reduction compared with calorie restriction (CR) or control.

Design:

12-month randomized controlled trial. (ClinicalTrials.gov: NCT04692532)

Setting:

University of Illinois Chicago from January 2021 to September 2022.

Participants:

90 adults with obesity.

Intervention:

8-hour TRE (eating between noon and 8:00 p.m. only, without calorie counting), CR (25% energy restriction daily), or control (eating over a period of 10 or more hours per day). Participants were not blinded.

Measurements:

Change in body weight, metabolic markers, and energy intake by month 12.

Results:

Seventy-seven persons completed the study. Mean age was 40 years (SD, 11), 33% were Black, and 46% were Hispanic. Mean reduction in energy intake was −425 kcal/d (SD, 531) for TRE and −405 kcal/d (SD, 712) for CR. Compared with the control group, weight loss by month 12 was −4.61 kg (95% CI, −7.37 to −1.85 kg; P ≤ 0.01) (−4.87% [CI, −7.61% to −2.13%]) for the TRE group and −5.42 kg (CI, −9.13 to −1.71 kg; P ≤ 0.01) (−5.30% [CI, −9.06% to −1.54%]) for the CR group, with no statistically significant difference between TRE and CR (0.81 kg [CI, −3.07 to 4.69 kg; P = 0.68]) (0.43% [CI, −3.48% to 4.34%]).

Limitation:

Not blinded, not powered to detect relatively large differences in weight loss, and lack of adjustment for multiple comparisons.

Conclusion:

Time-restricted eating is more effective in producing weight loss when compared with control but not more effective than CR in a racially diverse population.