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Biology (Basel).

Published online 2023 Jul 8.

Berberine and Its Study as an Antidiabetic Compound
Abstract
Simple Summary

Glucose is needed as the main source of energy in the body. However, too high sugar levels can lead to a variety of serious complications, including with the cardiovascular system, eyesight, and kidney function. The condition in which blood sugar levels are high is called hyperglycemia. Diabetes mellitus is a metabolic disease that causes hyperglycemia and is a disease that has been known to cause many deaths. Therefore, many treatments and preventive measures have been taken to fight diabetes mellitus. There are several oral diabetic drugs used, such as metformin, sulfonylureas, rosiglitazone, and others. However, some of these drugs have high risks or have contraindications with certain groups. Here, we discussed the mechanism of the natural compound berberine as an antidiabetic compound. In addition, we also found that berberine can work as an anti-inflammatory and antioxidant, where the state of inflammation and oxidative stress itself has an influence on the condition of diabetes mellitus.