Rottatutkimuksessa koe-eläimet jaettiin neljään ryhmään: runsasproteiininen ketogeeninen ruokavalio pätkäpaastoilun kera ja ilman sekä normiruokavalio pätkäpaastoilun kera ja ilman. Eniten laihduttiin ryhmässä keto plus paastoilu, toiseksi eniten ryhmässä keto ilman paastoilua ja kolmanneksi eniten ryhmässä normiruokavalio plus paastoilu.
Verensokeri laski eniten ryhmässä keto plus paastoilu.
Available online 7 September 2023
In Press, Journal Pre-proof
The role of insulin resistance and leptin in the effect of intermittent feeding with a high protein ketogenic diet on body composition in ratshttps://doi.org/10.1016/j.nut.2023.112213
•High-protein ketogenic diets and intermittent nutrition can be protective against obesity and metabolic syndrome.
•Intermittent-high protein ketogenic diet provides low body weight and does not harm body composition.
•High-protein ketogenic diets provides low fasting glucose levels and preserves basal insulin and leptin levels without disturbing the blood lipid profile.
The prevalence of obesity and overweight have been increasing rapidly since childhood in the world and threaten society with various chronic diseases, which are born with them. High-protein ketogenic diets and intermittent nutrition are thought to be protective against obesity and metabolic syndrome. However, the exact effects and results, insulin resistance, and the role of leptin in the functioning mechanism of these diets have not been fully elucidated. In this study, the roles of insulin resistance and leptin hormone in the effect of body composition were investigated with a diet created with a high-protein ketogenic diet and intermittent nutrition combination. Thirty-two young non-obese rats were randomly divided into four equal groups. Both the standard diet and the high-protein ketogenic diet were given as ad libitum and intermittent to the rats for 6 weeks. The body weight and fat mass of the rats were measured at the end of the experiment. The fasting glucose, leptin, insulin, HDL, LDL, and triglycerides were measured with the taken blood samples. The lowest body weight was observed in the intermittent and high-protein ketogenic diet group and followed by the free high-protein ketogenic diet and standard intermittent diet group, respectively. Also, the lowest body fat mass was observed in the intermittent and high-protein ketogenic diet group followed by the standard intermittent diet group. While there was no change in leptin, insulin, HDL, LDL, and triglyceride levels in any group, the lowest blood glucose rate was observed in the intermittent and high-protein ketogenic diet group. The results revealed that an intermittent high-protein ketogenic diet is more effective than others in weight loss without disrupting biochemical health parameters and the applied diets do not prevent growth and development.