karppaus.infon arkistoitu foorumi

These results raise the possibility that diabetes and DR may share common pathogenic features with cancer, and strict blood glucose control to prevent DR in patients with diabetes may further reduce cancer development.”

The inverse association of hyperlipidemia with cancer might be due to the increased risk of early cardiovascular mortality; however, a direct anti-cancer effect of high cholesterol levels is also possible.

I can never be thankful enough for the ease and simplicity of the original @dietdoctor site in its approach to low carb. And I’ll again emphasize I don’t begrudge anyone for taking on new interests and ventures — I genuinely hope the new efforts toward the SPC model prove helpful for many.

But I’ll concede, @DrEenfeldt, this was one commitment I was counting on, and I fully own that it’s especially pronounced for personal reasons. @DietDoctor was easily the best go-to site for beginners and lay audiences to low carb. You had pinged me on this important course of action last year, and of course, I was fully invested and wanted to further support it publicly.

Anyway, I again appreciate all that the site has done in its golden years, and I’m not going to belabor this point. But for my own closure, I have to come to terms with the reality that @DietDoctor will never again return to being focused on low-carb.

Abstract
Aims/hypothesis
The aim of this study was to evaluate the association of chronic complications with time in tight range (TITR: 3.9–7.8 mmol/l) and time in range (TIR: 3.9–10.0 mmol/l) in people with type 1 diabetes.

Methods
The prevalence of microvascular complications (diabetic retinopathy, diabetic nephropathy and diabetic peripheral neuropathy [DPN]) and macrovascular complications according to sensor-measured TITR/TIR was analysed cross-sectionally in 808 adults with type 1 diabetes. Binary logistic regression was used to evaluate the association between TITR/TIR and the presence of complications without adjustment, with adjustment for HbA1c, and with adjustment for HbA1c and other confounding factors (sex, age, diabetes duration, BMI, BP, lipid profile, smoking, and use of statins and renin–angiotensin–aldosterone system inhibitors).

Results
The mean TITR and TIR were 33.9 ± 12.8% and 52.5 ± 15.0%, respectively. Overall, 46.0% had any microvascular complication (34.5% diabetic retinopathy, 23.8% diabetic nephropathy, 16.0% DPN) and 16.3% suffered from any macrovascular complication. The prevalence of any microvascular complication, diabetic retinopathy, diabetic nephropathy and a cerebrovascular accident (CVA) decreased with increasing TITR/TIR quartiles (all ptrend<0.05). Each 10% increase in TITR was associated with a lower incidence of any microvascular complication (OR 0.762; 95% CI 0.679, 0.855; p<0.001), diabetic retinopathy (OR 0.757; 95% CI 0.670, 0.856; p<0.001), background diabetic retinopathy (OR 0.760; 95% CI 0.655, 0.882; p<0.001), severe diabetic retinopathy (OR 0.854; 95% CI 0.731, 0.998; p=0.048), diabetic nephropathy (OR 0.799; 95% CI 0.699, 0.915; p<0.001), DPN (OR 0.837; 95% CI 0.717, 0.977; p=0.026) and CVA (OR 0.651; 95% CI 0.470, 0.902; p=0.010). The independent association of TITR with any microvascular complication (OR 0.867; 95% CI 0.762, 0.988; p=0.032), diabetic retinopathy (OR 0.837; 95% CI 0.731, 0.959; p=0.010), background diabetic retinopathy (OR 0.831; 95% CI 0.705, 0.979; p=0.027) and CVA (OR 0.619; 95% CI 0.426, 0.899; p=0.012) persisted after adjustment for HbA1c. Similar results were obtained when controlling for HbA1c and other confounding factors.

Conclusions/interpretation
TITR and TIR are inversely associated with the presence of microvascular complications and CVA in people with type 1 diabetes. Although this study was not designed to establish a causal relationship, this analysis adds validity to the use of TITR and TIR as key measures in glycaemic management.

Study shows early blood sugar control reduces diabetes complications
June 4, 2024

Research from the Universities of Oxford and Edinburgh has demonstrated the long-term benefits of early and intensive blood glucose control in minimizing complications associated with type 2 diabetes.

These complications can include severe health issues like heart attacks, kidney failure, and vision loss. The findings stem from the UK Prospective Diabetes Study (UKPDS), one of the most extended clinical trials ever conducted in the field of diabetes, which utilized comprehensive NHS data.

Professor Rury Holman from Oxford’s Radcliffe Department of Medicine, and the Chief Investigator of the UKPDS, emphasized the importance of early diagnosis and treatment.

“Often, people live with type 2 diabetes for years without a diagnosis because the symptoms might not be apparent until there’s a significant rise in blood sugar levels,” he explained.

The UKPDS began in 1977, randomly assigning newly diagnosed type 2 diabetes patients to either an intensive glucose control regimen using medications like sulfonylureas, insulin, or metformin, or a conventional strategy focused mainly on diet.

The results published in 1998 after 20 years of trial, highlighted that effective blood glucose management significantly lowers the risk of diabetes-related complications, influencing global guidelines towards recommending intensive glucose control for all individuals with the condition.

Professor Holman pointed out that even after the official trial ended, and the treatment strategies among the participants aligned, those who initially received intensive treatment continued to experience better health outcomes. A follow-up study a decade later confirmed these benefits persisted.

Scientists Cure Diabetes With Stem Cell Therapy In World First

Chinese scientists have achieved a significant medical milestone by successfully curing a long-term type 2 diabetes patient using a novel cell therapy. This breakthrough, reported on April 30 in the journal Cell Discovery, represents the world’s first successful use of stem cell-derived islet transplantation for diabetes.

The patient, a 59-year-old who had been managing diabetes for 25 years, received a transplant of pancreatic cells derived from his own stem cells in 2021 at Shanghai Changzheng Hospital. Prior to this, he had experienced a severe decline in pancreatic islet function following a kidney transplant in 2017, necessitating daily insulin injections.

The innovative treatment involved converting the patient’s blood cells into stem cells, which were then transformed into pancreatic islet cells. Within 11 weeks of the transplant, the patient no longer required external insulin, and within a year, he was able to discontinue oral diabetes medication altogether. Follow-up examinations indicated restored pancreatic and normal kidney functions, suggesting the patient had been cured of diabetes.

Kun kaikkein kasvispainotteisimmin ja vähiten lihaa syöviä verrattiin tuskin lainkaan kasviksia nauttiviin lihansyöjiin, kasvissyöjien diabetesriski oli 11–15 prosenttia pienempi

When was the last time you saw a happy GP?? I’m excited to tell you about an amazing patient whose T2D is now sorted and FOUR drugs stopped ‘I love being a doctor’ @rcgp Just eat nutrient dense food that doesn’t put your blood sugar up

I am thrilled to share the latest work from my lab at @BYU! We investigated the effects of allulose, a rare sugar, on diet-induced obesity and type 2 diabetes (T2D) in rats. Over 12 weeks, allulose supplementation showed:
- Reduced body weight gain
- Improved insulin sensitivity
- Enhanced glucose regulation
- Lower food consumption
- Increased GLP-1 levels
Even further, allulose also prevented liver triglyceride accumulation and promoted mitochondrial uncoupling in adipose tissue. These findings highlight allulose's potential as a safe, effective intervention for managing obesity and T2D.

Overall, these are very encouraging results for what is fast becoming the most popular sweetener. We have just started up a human study to confirm some of these findings (and more).

The ADA implies you need sugar.
The AHA implies intermittent fasting is bad.
Diet Doctor suggests that broccoli is more satiating than eggs.

We believe these are no longer authorities you can trust.

Tuoreen suomalaisen tutkimuksen mukaaan liikunta ei pidennä elinaikaa.

https://www.mtvuutiset.fi/artikkeli/suo ... #gs.a9iu8h

Siitä on kuitenkin näyttöä, että diabeetikolle liikunnasta on hyötyä.