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With these lifestyle changes, she went from a size 16 to a 10 to 12, losing more than two stone, and lowering her HBA1C level to 46.

What were the main findings of the Indiana University trial on a very low-carbohydrate ketogenic diet for diabetes reversal or remission?

In the Indiana University trial, led by Sarah Hallberg, about 350 people chose to follow the standard of care for diabetes or to follow a very low-carbohydrate ketogenic diet, sometimes called a keto diet. Following a keto diet means eating very few carbohydrates, roughly 20-35 nonfiber grams of carbohydrates a day, to reach a state called ketosis, during which the body switches its primary energy source from glucose to fats. This helps control blood sugar levels by reducing the amount of carbs that cause blood sugar spikes. This way of eating allows low-carbohydrate, high-fat foods like beef, pork, chicken, fish and seafood; high-fat cheeses; and low-carbohydrate vegetables like avocado, spinach, eggplant, cucumber, zucchini, green peppers, broccoli and cauliflower. People eating this way can replace high-carb flour with almond and coconut flour and include healthy fats such as olive oil, butter and coconut oil. They avoid grains, sugars and most fruits to maintain stable, lower blood sugar levels.

The Indiana University study showed a big drop in medication use among people on the keto diet. About 60% of those using insulin stopped needing it entirely. Medication use went down a lot in the keto group, unlike the control group where it stayed the same or went up. Overall, 47% of people on the keto diet achieved remission or reversal after one year and 38% after two years. In the control group, 7-10% of people achieved remission or reversal after 1-2 years.

England’s National Health Service (NHS) has reported an 18% increase in the number of people with non-diabetic hyperglycaemia – also known as pre-diabetes.

The latest National Diabetes Audit shows that 3,615,330 people registered with a GP have pre-diabetes and are at a greater risk of developing type 2 diabetes (T2D). Compared to 2023 figures, this is up by more than half a million patients.

Toisaalta satunnaistetut kontrolloidut tutkimukset ovat osoittaneet, että vähähiilihydraattiset ketogeeniset ruokavaliot vähentävät tehokkaasti kardiovaskulaarisia riskitekijöitä (verensokeritasoja, glykoitunutta hemoglobiinia ja tiettyjä, mutta eivät kaikkia veren lipidejä), erityisesti ylipainoisilla tai lihavilla ja tyypin 2 potilailla.

Cost of diabetes to UK estimated at £14 billion, research shows

Posted on 19 June 2024

Diabetes cost the UK almost £14 billion in 2021/22, including more than £10 billion in direct costs to the NHS, according to the findings of a new study which looked at the direct and indirect costs of the disease.

Largely preventable complications are causing ‘untold hardship’ for people with diabetes and costing the UK healthcare system £6.2 billion a year, a leading cha… billion a year, a leading cha…

Published: 20 June 2024
Impact of systematic diabetes screening on peri-operative infections in patients undergoing cardiac surgery

Abstract
Detection of high glycated hemoglobin (A1c) is associated with worse postoperative outcomes, including predisposition to develop systemic and local infectious events. Diabetes and infectious Outcomes in Cardiac Surgery (DOCS) study is a retrospective case–control study aimed to assess in DM and non-DM cardiac surgery patients if a new screening and management model, consisting of systematic A1c evaluation followed by a specialized DM consult, could reduce perioperative infections and 30-days mortality. Effective July 2021, all patients admitted to the cardiac surgery of IRCCS ISMETT were tested for A1c. According to the new protocol, glucose values of patients with A1c ≥ 6% or with known diabetes were monitored. The diabetes team was activated to manage therapy daily until discharge or provide indications for the diagnostic-therapeutic process. Propensity score was used to match 573 patients managed according to the new protocol (the Screen+ Group) to 573 patients admitted before July 2021 and subjected to the traditional management (Screen−). Perioperative prevalence of infections from any cause, including surgical wound infections (SWI), was significantly lower in the Screen+ as compared with the Screen− matched patients (66 [11%] vs. 103 [18%] p = 0.003). No significant difference was observed in 30-day mortality. A1c analysis identified undiagnosed DM in 12% of patients without known metabolic conditions. In a population of patients undergoing cardiac surgery, systematic A1c evaluation at admission followed by specialist DM management reduces perioperative infectious complications, including SWI. Furthermore, A1c screening for patients undergoing cardiac surgery unmasks unknown DM and enhances risk stratification.

Study: A healthy diet is associated with a lower risk of type 2 diabetes, regardless of genetic risk
by University of Eastern Finland

Obesity and diabetes are on the rise worldwide. In Germany, around half of all adults are now slightly overweight, almost one in five is obese. More than 7% of the German population have diabetes and numbers are rising. Excessive sugar consumption causes illness and is a burden to the public purse: When individuals are too sick to work, health insurance costs increase.

That's why attention has now turned to the impact of sugary beverages. The consumption of soft drinks, colas, energy drinks and the like are seen as a main factor in the rise in obesity worldwide.

The World Health Organization (WHO) has long since recommended that such drinks be taxed. Germany's Minister of Food and Agriculture Cem Özdemir of the Greens, backed by nine of the country's 16 federal states, favors the idea. The states are now calling on Germany's federal government to consider introducing a sugar tax.

Plenty of benefits

According to a November 2023 study by Munich's Technical University, a special tax on sugary drinks could be very effective.

Researchers calculated that the measure could prevent up to 240,000 Type 2 diabetes cases over the next 20 years. It could also help avoid or significantly reduce the likeness of 17,000 to 30,000 deaths, scientists projected.

A total of up to €16 billion ($17 billion) could be saved in this period, researchers found, while €4 billion ($4.2 billion) alone could be saved in the health care system, as more cases of obesity-related illnesses could be avoided.

Overall, the German workforce would be blighted by fewer sick days and there would be fewer illness-related early retirements and deaths among the working-age labor force. Indeed, the German economy as a whole would benefit from a sugary drinks tax.

The 34-year-old helped devise a nutrition plan for Hagar. It is based on the so-called "slow carb" diet, which includes high-protein foods such as eggs, fish, and chicken and vegetables, especially legumes, such as lentils and beans.

"We cut out all bread, processed food, and simple sugars," Conway said. Hagar said the diet was responsible for limiting her glycemic response. She reversed her diabetes and stopped taking medication last November.

Published: 16 May 2024
Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials

Chih-Chen Tzang, Liang-Yun Chi, …Levent Özçakar Show authors
Nutrition & Diabetes volume 14, Article number: 29 (2024)


Abstract
Background
Metabolic syndrome (MetS) is a cluster of interconnected risk factors that significantly increase the likelihood of cardiovascular disease and type 2 diabetes. Taurine has emerged as a potential therapeutic agent for MetS. This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of taurine supplementation on MetS-related parameters.

Methods
We conducted electronic searches through databases like Embase, PubMed, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov, encompassing publications up to December 1, 2023. Our analysis focused on established MetS diagnostic criteria, including systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). Meta-regression explored potential dose-dependent relationships based on the total taurine dose administered during the treatment period. We also assessed secondary outcomes like body composition, lipid profile, and glycemic control.

Results
Our analysis included 1024 participants from 25 RCTs. The daily dosage of taurine in the studies ranged from 0.5 g/day to 6 g/day, with follow-up periods varying between 5 and 365 days. Compared to control groups, taurine supplementation demonstrated statistically significant reductions in SBP (weighted mean difference [WMD] = −3.999 mmHg, 95% confidence interval [CI] = −7.293 to −0.706, p = 0.017), DBP (WMD = −1.509 mmHg, 95% CI = −2.479 to −0.539, p = 0.002), FBG (WMD: −5.882 mg/dL, 95% CI: −10.747 to −1.018, p = 0.018), TG (WMD: −18.315 mg/dL, 95% CI: −25.628 to −11.002, p < 0.001), but not in HDL-C (WMD: 0.644 mg/dl, 95% CI: −0.244 to 1.532, p = 0.155). Meta-regression analysis revealed a dose-dependent reduction in DBP (coefficient = −0.0108 mmHg per g, p = 0.0297) and FBG (coefficient = −0.0445 mg/dL per g, p = 0.0273). No significant adverse effects were observed compared to the control group.

Conclusion
Taurine supplementation exhibits positive effects on multiple MetS-related factors, making it a potential dietary addition for individuals at risk of or already experiencing MetS. Future research may explore dose-optimization strategies and potential long-term benefits of taurine for MetS management.

Meat consumption without grains & sugar improves glycemia in diabetes, can help prevent osteopenia and sarcopenia and has been shown in a low carb diet to outperform the DASH diet

This is called promoting human health.

Lying about meat would be deciding to promote cruelty to humans which is what you do

My recent HbA1c is 5.4% as compared to 11.7% of last year. Reduced 30 kg of weight by following low carb diet and regular exercise.

Insuliinin aiheuttama lipohypertrofia
Tekijät : Nirmalya Roy , MB, BS, MD ja Mainak Mandal , MB, BS https://orcid.org/0009-0002-7226-2598
Julkaistu 19. kesäkuuta 2024
N Engl J Med 2024 ; 390 : e60
DOI: 10.1056/NEJMicm2314962
VOL. 390 NO 2
Tyypin 2 diabetesta sairastava 65-vuotias mies vietiin sairaalaan hyperosmolaarisen hyperglykeemisen tilan vuoksi. Kaksi viikkoa ennen vastaanottoa potilaan insuliiniannosta oli korotettu riittämättömän glukoositasapainon vuoksi. Fyysisessä tarkastuksessa havaittiin hämmennystä ja sarkopeniaa. Napan kummallakin puolella oli myös kumimaisia, ihonalaisia ​​massoja, joissa potilas oli toistuvasti antanut insuliiniruiskeita - tämä löydös tunnetaan insuliinin aiheuttamana lipohypertrofiana. Insuliinin aiheuttama lipohypertrofia on eräänlainen paikallinen lipodystrofia, joka johtuu toistuvista ihonalaisista injektioista samaan kohtaan. Se voi johtaa heikentyneeseen vasteeseen insuliinihoitoon ja haihtuviin glykeemisiin tasoihin. Lipohypertrofiaa voi olla vaikea havaita lihavilla potilailla, mutta massat ovat yleensä käsin kosketeltavissa vatsan tutkimuksessa. Ihonalaista insuliinia käyttävät potilaat tulee tutkia pistoskohdan komplikaatioiden varalta jokaisella klinikkakäynnillä, ja heidän tulee saada neuvontaa pistoskohdan vaihtamisen tärkeydestä, jotta kohdat paranevat. Tällä potilaalla laboratoriotutkimuksissa havaittiin 11,4 %:n glykoituneen hemoglobiinin taso (vertailualue <7). 48 tunnin insuliini- ja suonensisäisten nesteiden hoidon jälkeen potilaan hyperosmolaarinen hyperglykeeminen tila parani. Hänet päästettiin kotiin saatuaan ohjeet ihonalaisen insuliinin oikeasta antamisesta.