They took blockbuster drugs for weight loss and diabetes. Now their stomachs are paralyzed

Despite the drug’s widespread popularity, critics have expressed their reservations. Semaglutide does have side effects, notably nausea and diarrhea but also more serious side effects like low blood sugar and kidney failure.
Ozempic is also not a cure. Patients who stop taking it can regain some or all of the weight they lost. There is also the issue of affordability: Ozempic isn’t cheap. Although less expensive than in many other countries, in Canada Ozempic costs about $200 to $300 per month.

"Toivon, etten olisi koskaan koskenut siihen" – huippusuosittu laihdutuslääke voikin aiheuttaa mahalaukun halvauksen?

“For me, the first few weeks was f*****g s**t because you just throw up all the time. You feel so nauseous,” Osbourne said. “After a couple of weeks it goes.”

Mahalaukun ”halvaantuminen” eli tyhjentymishäiriö (gastropareesi) syklisine oksentelujaksoineen ei kuulosta mukavalta sivuvaikutukselta.

A lawsuit has been filed in the US claiming that Novo Nordisk and Eli Lilly failed to warn of severe gastrointestinal side effects that can be caused by their incretin mimetic drugs, which are approved to treat diabetes.

Louisiana woman Jaclyn Bjorklund (44) took Novo Nordisk's GLP-1 agonist Ozempic (semaglutide) for a year for type 2 diabetes and later switched to using Lilly's combined GLP-1/GIP agonist Mounjaro (tirzepatide).

She is suing the two pharma companies for "downplaying" the risk of side effects including gastroparesis, described in the complaint as paralysed stomach, and gastroenteritis, claiming she suffered "severe gastrointestinal events, and as a result sustained severe and permanent personal injuries, pain, suffering, and emotional distress, and incurred medical expenses."

Miehelleni määrättiin Ozempicia diabeteksen hoitoon. Sen jälkeen hän sai aivan hirveän ripulin. Sitä ihmeteltiin melkein vuosi, ennen kuin selvisi, että se johtuu Ozempicista.

Denmark should stop subsidising the use of Ozempic and other so-called GLP-1 drugs for patients suffering from type 2 diabetes, and instead pay for cheaper drugs as a preferred first option, a public commission said in a recommendation issued on Tuesday.

The proposal will be subject to a hearing until Oct. 8, after which a decision will be made by the Danish Medicines Agency.

While GLP-1 drugs are significantly more expensive than other options, there is no general advantage in the treatment of patients suffering from type 2 diabetes, the commission said in a statement.

"As a result, they should not be the preferred choice for patients with type 2 diabetes," it said, while adding that exemptions could be made in certain cases.

Some 87,400 Danes received subsidised GLP-1 drugs for type 2 diabetes last year, according to the medicines agency.

Danish drug maker Novo Nordisk (NOVOb.CO) has seen a surge in demand for Ozempic and its sister drug Wegovy, a weight-loss medication based on similar ingredients.

6/8 However we are heading for yet another medical disaster with the inception of Semaglutide. We are merely papering over cracks and ignoring the huge elephant in the room.

“There will absolutely be no overeating with Wegovy or semaglutide because you will feel awful, completely awful, so no overeating or that full feeling. You'll probably never feel that again,” she warned.

Ozempic is designed to be a long-term medication. “For patients who are responders to these medications, we would recommend that [they] should stay on these indefinitely,” Dr. Stanford says.

That said, doctors ultimately don’t yet know what the potential long-term effects of using this medication to treat obesity may be.

But if you stop taking it long-term, “there’s a pretty high chance of weight regain,” Dr. Shah says. The risk of health complications like heart attack, stroke, and type 2 diabetes also rises with weigh regain, he points out.

CNN
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The US Food and Drug Administration has updated the label of the diabetes drug Ozempic to acknowledge reports of blocked intestines in some people using the medication.

Ozempic and its sister drug, Wegovy, which is approved for weight loss, have recently soared in popularity. They use a medication called semaglutide, part of a family of drugs called GLP-1 agonists, which work by mimicking a hormone that the body naturally makes to slow the passage of food through the stomach, which helps people feel fuller longer.

The labels of Wegovy and a diabetes drug called Mounjaro acknowledge reports of a condition called ileus, or intestinal blockage, in some people who use them. Ozempic’s label has been updated to say the same.

Ozempic weight loss: 40% of the loss was muscle mass.

If you eat the same crap as you ate before, just less of it, and don't do resistance training, you're going to lose a lot of muscle.

Most people will need to take this drug for life

Diabetesliiton lääkäri Elina Pimiä muistuttaa, että kyseessä ei välttämättä ole ihmelääke lihavuusongelmaan.

… kun sen käyttö lopetetaan, elimistö yrittää palata entiseen.

Ozempic burned my genitals and butt - leaving 'pieces of skin' falling off and causing excruciating pain