Epidemiology of ischaemic heart disease in India with special reference to causation
S L Malhotra
1967;29;895-905 Heart
Lainaa:
The study concerns 1 -15 million
railway workers between the ages of 18-55 years serving
on the 8 zonal railways in different parts of India. The
period studied was from January 1, 1958, to December
31, 1962.
...
There is much evidence that ischaemic
heart disease is caused by the kind and quantity of
food eaten, especially the amount of animal fat
(Kinsell et al., 1952; Kinsell, 1964; Ahrens et al.,
1958; Keys, 1956, 1964; and others). Our data,
however, do not support this association of high fat
intake with the liability to develop ischemic heart
disease, because while in the north the consumption
of fats, most of which are animal fats, is 19 times
more than in the south (Indian Council of Medical
Research, 1964), the disease is 7 times less in the
north than in the south. Moreover, while the
milk fats eaten in the north have a preponderance of
saturated fatty acids, the seed oils used in the south
are mainly composed of unsaturated fatty acids
(Indian Council of Medical Rsearch, 1963). This
inverse association is noteworthy, especially because
others have also observed this association of high
intake of animal fats and freedom from cardio-
vascular disease (Shaffer et al., 1964; Shaper, Jones,
and Kyobe, 1961; Mann, Shaffer, and Rich, 1965).
This evidence from other studies and our additional
findings of the inverse association of a low intake of
total as well as animal fats and a high frequency of
ischemic heart disease in the south are contrary to
the view that it is the quantity of dietary fats and
their degree of saturation that bear responsibility for
cases of this disease.
http://heart.bmj.com/cgi/reprint/29/6/895
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